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Also, differential expression of GR-chaperones, transcriptional co-regulators, or differences in phosphorylation status of the receptor, may all contribute significantly to the effects of antidepressants on GR-dependent changes in glucocorticoid resistance, hippocampal volume and neurogenesis.
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Nervous System: frequent: hypesthesia, apathy, depression, hypokinesia, vertigo, twitching, agitation, anxiety, amnesia, hyperkinesia, paresthesia; infrequent: ataxia, delirium, delusions, depersonalization, dyskinesia, extrapyramidal syndrome, libido increased, coordination abnormal, dysarthria, hallucinations, manic reaction, neurosis, dystonia, hostility, reflexes increased, emotional lability, euphoria, paranoid reaction; rare: aphasia, nystagmus, akathisia (psychomotor restlessness), stupor, dementia, diplopia, drug dependence, paralysis, grand mal convulsion, hypotonia, myoclonus, psychotic depression, withdrawal syndrome, serotonin syndrome.
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Rates of suicide and attempted suicide or self harm were lowest during periods when patients were not taking antidepressants, but this is likely to reflect the absence of current depression or less severe depression during those periods rather than an indication that antidepressant treatment in itself increases the risks of suicide and attempted suicide or self harm.
Bisson JI, Ehlers A, Matthews R, Pilling S, Richards D, Turner S (2007).
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Neurology and Urodynamics. Whats more, the effects seemed to last at least two weeks beyond the test period.
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Norepinephrine is a stimulating neurotransmitter and serotonin is a neurotransmitter associated with relaxation and comfort; increasing the brain levels of these substances could be helpful in treating depression.
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Olfson M, King M, Schoenbaum M. Treatment of young people with antipsychotic medication in the US.
Although there are no human data pertinent to such an interaction with REMERON (mirtazapine) Tablets, it is recommended that REMERON not be used in combination with an MAOI, or within 14 days of initiating or discontinuing therapy with an MAOI.
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